Major Depressive Disorder: A Comparative Study on Socio-Emotional Cognition and Executive Functions
DOI:
https://doi.org/10.1590/0102.3772e38217.pt%20Keywords:
Major Depressive Disorder; Executive functions; Socio-emotional cognition; Empathy.Abstract
The present study aimed to assess socioemotional cognition and executive functions in patients with unipolar Major Depressive Disorder. The sample included 22 patients between 36 and 93 years of age (M = 59.32; SD = 12.89) and 23 patients between 30 and 81 years of age (M = 63.00; SD = 13.56) controls. In addition to demographic data, symptoms of anxiety and depression, empathy, theory of mind, recognition of emotions, inhibitory control, cognitive flexibility and phonemic verbal fluency were obtained. There was no statistical difference between the groups regarding age and education. Patients had significantly more anxiety, depression and personal distress than controls. Individuals with more severe depressive symptoms had a lower processing speed than the others.
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Aker, M., Harmer, C., & Landro, N. I. (2014). More rumination and less effective emotion regulation in previously depressed women with preserved executive functions. BMC Psychiatry, 14(1), 334. https://doi.org/10.1186/s12888-014-0334-4
American Psychiatric Association. (2014). Manual Diagnóstico e Estatístico de Transtornos Mentais - DSM-5. Porto Alegre: Artmed.
Amorim, P. (2000). Mini International Neuropsychiatric Interview (MINI): Validação de entrevista breve para diagnóstico de transtornos mentais. Revista Brasileira de Psiquiatria, 22(3), 106–115. https://doi.org/10.1590/S1516-44462000000300003
Austin, M. P., Mitchell, P., & Goodwin, G. M. (2001). Cognitive deficits in depression: Possible implications for functional neuropathology. The British Journal of Psychiatry, 178(3), 200–206. https://doi.org/10.1192/bjp.178.3.200
Beato, R., Amaral-Carvalho, V., Guimarães, H. C., Tumas, V., Souza, C. P., Oliveira, G. N. De, & Caramelli, P. (2012). Frontal assessment battery in a Brazilian sample of healthy controls: Normative data. Arquivos de Neuro-Psiquiatria, 70(4), 278–280. https://doi.org/10.1590/S0004-282X2012005000009
Beato, R. G., Nitrini, R., Formigoni, A. P., & Caramelli, P. (2007). Brazilian version of the Frontal Assessment Battery (FAB): Preliminary data on administration to healthy elderly. Dementia & Neuropsychologia, 1(1), 59–65. https://doi.org/10.1590/S1980-57642008DN10100010
Bediou, B., Brunelin, J., d’Amato, T., Fecteau, S., Saoud, M., Hénaff, M. A., & Krolak-Salmon, P. (2012). A comparison of facial emotion processing in neurological and psychiatric conditions. Frontiers in Psychology, 3(APR), 1–10. https://doi.org/10.3389/fpsyg.2012.00098
Bertoux, M., Delavest, M., de Souza, L. C., Funkiewiez, a., Lepine, J.-P., Fossati, P., … Sarazin, M. (2012). Social Cognition and Emotional Assessment differentiates frontotemporal dementia from depression. Journal of Neurology, Neurosurgery & Psychiatry, 83(4), 411–416. https://doi.org/10.1136/jnnp-2011-301849
Bora, E., Harrison, B. J., Yücel, M., & Pantelis, C. (2013). Cognitive impairment in euthymic major depressive disorder: a meta-analysis. Psychological Medicine, 43(10), 2017–2026. https://doi.org/10.1017/S0033291712002085
Botega, N. J., Bio, M. R., Zomignani, M. A., Garcia Jr, C., & Pereira, W. A. B. (1995). Transtornos do humor em enfermaria de clínica médica e validação de escala de medida (HAD) de ansiedade e depressão. Revista de Saúde Pública, 29(5), 359–363. https://doi.org/10.1590/S0034-89101995000500004
Boyraz, G., & Waits, J. B. (2015). Reciprocal associations among self-focused attention, self-acceptance, and empathy: A two-wave panel study. Personality and Individual Differences, 74, 84–89. https://doi.org/10.1016/j.paid.2014.09.042
Cohen, J. (1988). Statistical power analysis for the behavioral sciences (2.ª ed.). Hillsdale: Lawrence Erlbaum Associates.
Cotter, J., Granger, K., Backx, R., Hobbs, M., Looi, C. Y., & Barnett, J. H. (2018). Social cognitive dysfunction as a clinical marker: a systematic review of meta-analyses across 30 clinical conditions. Neuroscience & Biobehavioral Reviews, 84, 92-99. https://doi.org/10.1016/j.neubiorev.2017.11.014
Cusi, A. M., MacQueen, G. M., Spreng, R. N., & McKinnon, M. C. (2011). Altered empathic responding in major depressive disorder: Relation to symptom severity, illness burden, and psychosocial outcome. Psychiatry Research, 188(2), 231–236. https://doi.org/10.1016/j.psychres.2011.04.013
Cusi, A. M., Nazarov, A., MacQueen, G. M., & McKinnon, M. C. (2013). Theory of mind deficits in patients with mild symptoms of major depressive disorder. Psychiatry Research, 210(2), 672–674. https://doi.org/10.1016/j.psychres.2013.06.018
Darcet, F., Gardier, A., Gaillard, R., David, D., & Guilloux, J.-P. (2016). Cognitive dysfunction in Major Depressive Disorder: A translational review in animal models of the disease. Pharmaceuticals, 9(1), 9. https://doi.org/10.3390/ph9010009
Devine, R. T., & Hughes, C. (2014). Relations between false belief understanding and executive function in early childhood: A meta-analysis. Child development, 85(5), 1777-1794. doi: 10.1111/cdev.12237
Dubois, B., Slachevsky, A., Litvan, I., & Pillon, B. (2000). The FAB: A frontal assessment battery at bedside. Neurology, 55(11), 1621–1626. https://doi.org/10.1212/WNL.57.3.565
Funkiewiez, A., Bertoux, M., de Souza, L. C., Lévy, R., & Dubois, B. (2012). The SEA (Social Cognition and Emotional Assessment): A clinical neuropsychological tool for early diagnosis of frontal variant of frontotemporal lobar degeneration. Neuropsychology, 26(1), 81–90. https://doi.org/10.1037/a0025318
Fiorillo, A., Carpiniello, B., De Giorgi, S., La Pia, S., Maina, G., Sampogna, G., Spina, E., Tortorella, A., … Vita, A. (2018). Assessment and management of cognitive and psychosocial dysfunctions in patients with Major Depressive Disorder: A clinical review. Frontiers in psychiatry, 9, 493. doi:10.3389/fpsyt.2018.00493
Gollan, J. K., McCloskey, M., Hoxha, D., & Coccaro, E. F. (2010). How do depressed and healthy adults interpret nuanced facial expressions? Journal of Abnormal Psychology, 119(4), 804–810. https://doi.org/10.1037/a0020234
Gollan, J. K., Pane, H. T., McCloskey, M. S., & Coccaro, E. F. (2008). Identifying differences in biased affective information processing in major depression. Psychiatry Research, 159(1–2), 18–24. https://doi.org/10.1016/j.psychres.2007.06.011
Hammer-Helmich, L., Haro, J. M., Jönsson, B., Tanguy Melac, A., Di Nicola, S., Chollet, J., Milea, D., Rive, B., … Saragoussi, D. (2018). Functional impairment in patients with major depressive disorder: The 2-year PERFORM study. Neuropsychiatric disease and treatment, 14, 239-249. doi:10.2147/NDT.S146098
Inoue, Y., Tonooka, Y., Yamada, K., & Kanba, S. (2004). Deficiency of theory of mind in patients with remitted mood disorder. Journal of Affective Disorders, 82(3), 403–409. https://doi.org/10.1016/j.jad.2004.04.004
Knight, M. J., & Baune, B. T. (2018). Executive subdomains are differentially associated with psychosocial outcomes in Major Depressive Disorder. Frontiers in psychiatry, 9, 309. doi:10.3389/fpsyt.2018.00309
Lee, L., Harkness, K. L., Sabbagh, M. A., & Jacobson, J. A. (2005). Mental state decoding abilities in clinical depression. Journal of Affective Disorders, 86(2–3), 247–258. https://doi.org/10.1016/j.jad.2005.02.007
Leppänen, J. M., Milders, M., Bell, J. S., Terriere, E., & Hietanen, J. K. (2004). Depression biases the recognition of emotionally neutral faces. Psychiatry Research, 128(2), 123–133. https://doi.org/10.1016/j.psychres.2004.05.020
Matthews, S. C., Strigo, I. A., Simmons, A. N., Yang, T. T., & Paulus, M. P. (2008). Decreased functional coupling of the amygdala and supragenual cingulate is related to increased depression in unmedicated individuals with current major depressive disorder. Journal of Affective Disorders, 111(1), 13–20. https://doi.org/10.1016/j.jad.2008.05.022
Millan, M. J., Agid, Y., Brüne, M., Bullmore, E. T., Carter, C. S., Clayton, N. S., ... & Dubois, B. (2012). Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy. Nature reviews Drug discovery, 11(2), 141. https://dx.doi.org/10.1038/nrd3628
Mor, N., & Winquist, J. (2002). Self-focused attention and negative affect: A meta-analysis. Psychological Bulletin, 128(4), 638–662. https://doi.org/10.1037/0033-2909.128.4.638
Roca, M., Vives, M., Lopez-Navarro, E., Garcia-Campayo, J., & Gili, M. (2015). Cognitive impairments and depression: A critical review. Actas Espanolas de Psiquiatria, 43(5), 187–193.
Santamaría-García, H., Baez, S., Gómez, C., Rodríguez-Villagra, O., Huepe, D., Portela, M., ... & Ibanez, A. (2020). The role of social cognition skills and social determinants of health in predicting symptoms of mental illness. Translational psychiatry, 10(1), 165. https://doi.org/10.1038/s41398-020-0852-4
Schreiter, S., Pijnenborg, G. H. M., & Aan Het Rot, M. (2013). Empathy in adults with clinical or subclinical depressive symptoms. Journal of Affective Disorders, 150(1), 1–16. https://doi.org/10.1016/j.jad.2013.03.009
Shahaeian, A., Henry, J. D., Razmjoee, M., Teymoori, A., & Wang, C. (2014). Towards a better understanding of the relationship between executive control and theory of mind: an intra-cultural comparison of three diverse samples. Developmental Science, 18(5), 671-685. https://doi.org/10.1111/desc.12243
Snyder, H. R. (2013). Major depressive disorder is associated with broad impairments on neuropsychological measures of executive function: A meta-analysis and review. Psychological Bulletin, 139(1), 81–132. https://doi.org/10.1037/a0028727
Steiner, V. A. G., Mansur, L. L., Brucki, S. M. D., & Nitrini, R. (2008). Phonemic verbal fluency and age: A preliminary study. Dementia & Neuropsychologia, 2(4), 328–332.
Suslow, T., Konrad, C., Kugel, H., Rumstadt, D., Zwitserlood, P., Schöning, S., … Dannlowski, U. (2010). Automatic mood-congruent amygdala responses to masked facial expressions in Major Depression. Biological Psychiatry, 67(2), 155–160. https://doi.org/10.1016/j.biopsych.2009.07.023
Thoma, P., Zalewski, I., von Reventlow, H. G., Norra, C., Juckel, G., & Daum, I. (2011). Cognitive and affective empathy in depression linked to executive control. Psychiatry Research, 189(3), 373–378. https://doi.org/10.1016/j.psychres.2011.07.030
Uekermann, J., Channon, S., Lehmkämper, C., Abdel-Hamid, M., Vollmoeller, W., & Daum, I. (2008). Executive function, mentalizing and humor in major depression. Journal of the International Neuropsychological Society, 14(1), 55-62. https://doi.org/10.1017/S1355617708080016
Wagner, S., Helmreich, I., Wollschläger, D., Meyer, K., Kaaden, S., Reiff, J., Roll, S. C., Braus, D., Tüscher, O., Müller-Dahlhaus, F., Tadic, A., … Lieb, K. (2018). Early improvement of executive test performance during antidepressant treatment predicts treatment outcome in patients with Major Depressive Disorder. PloS one, 13(4), e0194574. doi:10.1371/journal.pone.0194574
Wang, Y. G., Wang, Y. Q., Chen, S. L., Zhu, C. Y., & Wang, K. (2008). Theory of mind disability in major depression with or without psychotic symptoms: A componential view. Psychiatry Research, 161(2), 153–161. https://doi.org/10.1016/j.psychres.2007.07.018
Weightman, M. J., Air, T. M., & Baune, B. T. (2014). A review of the role of social cognition in major depressive disorder. Frontiers in Psychiatry, 5, 179. https://doi.org/10.3389/fpsyt.2014.00179
Yamada, K., Inoue, Y., & Kanba, S. (2015). Theory of mind ability predicts prognosis of outpatients with major depressive disorder. Psychiatry Research, 230(2), 604–608. https://doi.org/10.1016/j.psychres.2015.10.011
Zaremba, D., Kalthoff, I. S., Förster, K., Redlich, R., Grotegerd, D., Leehr, E. J., … & Dannlowski, U. (2019). The effects of processing speed on memory impairment in patients with major depressive disorder. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 92, 494-500. https://doi.org/10.1016/j.pnpbp.2019.02.015
Zimmermann, N., Cardoso, C. O., Kristensen, C. H., & Fonseca, R. P. (2017). Brazilian norms and effects of age and education on the Hayling and Trail Making Tests. Trends in Psychiatry and Psychotherapy, 39(3), 188-195. https://dx.doi.org/10.1590/2237-6089-2016-0082
Zuckerman, H., Pan, Z., Park, C., Brietzke, E., Musial, N., Shariq, A. S., Iacobucci, M., Yim, S. J., Lui, L., Rong, C., & McIntyre, R. S. (2018). Recognition and Treatment of Cognitive Dysfunction in Major Depressive Disorder. Frontiers in psychiatry, 9, 655. https://doi.org/10.3389/fpsyt.2018.00655
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Copyright (c) 2022 Bruna Gomes Monego, Rochele Paz Fonseca, Antônio Lúcio Teixeira, Izabela Guimarães Barbosa, Leonardo Cruz de Souza, Denise Ruschel Bandeira
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