DÉFICITS NA MEMÓRIA DE TRABALHO EM IDOSOS COM DEPRESSÃO MAIOR:
UMA REVISÃO SISTEMÁTICA
Palavras-chave:
Psicogeriatria; Psiquiatria Geriátrica, Memória operacional, Memória de curta duração, Depressão geriátrica, Cognição, Idosos, NeuropsicologiaResumo
Alguns estudos observaram declínio neuropsicológico em idosos deprimidos, todavia nem todos os aspectos da cognição estariam envolvidos. Particularmente a Memória de Trabalho (MT) seria uma das funções mais afetadas. Portanto o objetivo deste artigo é apresentar quais são as evidências sobre prejuízos na MT em idosos portadores de depressão maior. Através de uma revisão sistemática de artigos publicados entre 2000-2011 nas bases de dados Medline, PsycINFO, Cochrane, Scielo, Lilacs e Web of Science (ISI), publicados em inglês, português e espanhol, buscou-se as seguintes palavras chaves: working memory, depression and elderly or elder or aginig or aged or ageing. Após análise, seguindo critérios de inclusão e exclusão, foram analisados 17 artigos. A maioria destes evidenciando prejuízos significativos da MT em participantes depressivos. Prejuízos que parecem permanecer mesmo após a remissão dos sintomas.
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Referências
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Baddeley, A. (2009). Working memory. In A. Baddeley, M. Anderson & M. Eysenck (Eds.), Memory (pp. 41-68). Hove: Psychology Press.
Birch, L. S., & Davidson, K. M. (2007). Specificity of autobiographical memory in depressed older adults and its relationship with working memory and IQ. The British Journal of Clinical Psychology, 46(Pt 2), 175-186. doi: 10.1348/014466506X119944
Chui, W. W., Cheung, E. F., & Lam, L. C. (2011). Neuropsychological profiles and short-term outcome in late-onset depression. International Journal of Geriatric Psychiatry, 26(5), 458-465. doi: 10.1002/gps.2548
Delaloye, C., Baudois, S., de Bilbao, F., Dubois Remund, C., Hofer, F., Lamon, M., . . . Giannakopoulos, P. (2008). Cognitive impairment in late-onset depression. Limited to a decrement in information processing resources? European Neurology, 60(3), 149-154. doi: 000144086 [pii] 10.1159/000144086
Delaloye, C., de Bilbao, F., Moy, G., Baudois, S., Weber, K., Campos, L., & Gold, G. (2009). Neuroanatomical and neuropsychological features of euthymic patients with bipolar disorder. American Journal of Geriatric Psychiatry, 17(12), 1012-1021. doi: 00019442-200912000-00004 [pii] 10.1097/JGP.0b013e3181b7f0e2
Delaloye, C., Moy, G., de Bilbao, F., Baudois, S., Weber, K., Hofer, F., & Gold, G. (2010). Neuroanatomical and neuropsychological features of elderly euthymic depressed patients with early-and-late-onset. Journal of the Neurological Sciences, 299(1-2), 19-23. doi: S0022-510X(10)00413-2 [pii] 10.1016/j.jns.2010.08.046
Elderkin-Thompson, V., Kumar, A., Bilker, W. B., Dunkin, J. J., Mintz, J., Moberg, P. J., ... Gur, R. E. (2003). Neuropsychological deficits among patients with late-onset minor and major depression. Archives of Clinical Neuropsychology, 18(5), 529-549. doi: S0887617703000222 [pii]
Fischer, C., Schweizer, T. A., Atkins, J. H., Bozanovic, R., Norris, M., Herrmann, N., ... Rourke, S. B. (2008). Neurocognitive profiles in older adults with and without major depression. International Journal of Geriatric Psychiatry, 23(8), 851-856. doi: 10.1002/gps.1994
Fiske, A., Wetherell, J. L., & Gatz, M. (2009). Depression in older adults. Annual Review of Clinical Psychology, 5, 363-389. doi: 10.1146/annurev.clinpsy.032408.153621
Foldi, N. S., Brickman, A. M., Schaefer, L. A., & Knutelska, M. E. (2003). Distinct serial position profiles and neuropsychological measures differentiate late life depression from normal aging and Alzheimer’s disease. Psychiatry Research, 120(1), 71-84. doi: S016517810300163X [pii]
Goffaux, P., Phillips, N. A., Sinai, M., & Pushkar, D. (2008). Neurophysiological measures of task-set switching: effects of working memory and aging. The Journals of Gerontology: Series B, Psychology Social Sciences, 63(2), P57-66. doi: 63/2/P57 [pii]
Herrmann, L. L., Goodwin, G. M., & Ebmeier, K. P. (2007). The cognitive neuropsychology of depression in the elderly. Psychological Medicine, 37(12), 1693-1702. doi: S0033291707001134 [pii] 10.1017/S0033291707001134
Lonie, J. A., Tierney, K. M., Herrmann, L. L., Donaghey, C., O’Carroll, R. E., Lee, A., & Ebmeier, K. P. (2009). Dual task performance in early Alzheimer’s disease, amnestic mild cognitive impairment and depression. Psychological Medicine, 39(1), 23-31. doi: S0033291708003346 [pii] 10.1017/S0033291708003346
Luo, L., & Craik, F. I. (2008). Aging and memory: A cognitive approach. Canadian Journal of Psychiatry, 53(6), 346-353.
Mondal, S., Sharma, V. K., Das, S., Goswami, U., & Gandhi, A. (2007). Neuro-cognitive functions in patients of major depression. Indian Journal of Physiology Pharmacology, 51(1), 69-75.
Murray, L. (2002). Cognitive distinctions between depression and early Alzheimer’s disease in the elderly. Aphasiology, 16(4/5/6), 573-585. doi: 10.1080/02687030244000293
Nebes, R. D., Butters, M. A., Houck, P. R., Zmuda, M. D., Aizenstein, H., Pollock, B. G., Reynolds, C. F. (2001). Dual-task performance in depressed geriatric patients. Psychiatry Research, 102(2), 139-151. doi: S0165-1781(01)00244-X [pii]
Nebes, R. D., Butters, M. A., Mulsant, B. H., Pollock, B. G., Zmuda, M. D., Houck, P. R., & Reynolds, C. F. (2000). Decreased working memory and processing speed mediate cognitive impairment in geriatric depression. Psychological Medicine, 30(3), 679-691.
Nebes, R. D., Pollock, B. G., Houck, P. R., Butters, M. A., Mulsant, B. H., Zmuda, M. D., & Reynolds, C. F. (2003). Persistence of cognitive impairment in geriatric patients following antidepressant treatment: A randomized, double-blind clinical trial with nortriptyline and paroxetine. Jounal of Psychiatry Research, 37(2), 99-108. doi: S0022395602000857 [pii]
Nyberg, L., Dahlin, E., Stigsdotter Neely, A., & Bäckman, L. (2009). Neural correlates of variable working memory load across adult age and skill: Dissociative patterns within the fronto-parietal network. Scandinavian Journal of Psychology, 50(1), 41-46. doi: SJOP678 [pii] 10.1111/j.1467-9450.2008.00678.x
O’Brien, J. T., Lloyd, A., McKeith, I., Gholkar, A., & Ferrier, N. (2004). A longitudinal study of hippocampal volume, cortisol levels, and cognition in older depressed subjects. American Journal of Psychiatry, 161(11), 2081-2090. doi: 161/11/2081 [pii] 10.1176/appi.ajp.161.11.2081
Owen, A. M., McMillan, K. M., Laird, A. R., & Bullmore, E. (2005). N-back working memory paradigm: A meta-analysis of normative functional neuroimaging studies. Human Brain Mapping, 25(1), 46-59. doi: 10.1002/hbm.20131
Rozenthal, M., Laks, J., & Egekhardt, E. (2004). Aspectos neuropsicológicos da depressão. Revista de Psiquiatria do Rio Grande do Sul, 26(2), 204-212.
Sair, H. I., Welsh-Bohmer, K. A., Wagner, H. R., & Steffens, D. C. (2006). Ascending digits task as a measure of executive function in geriatric depression. Journal of Neuropsychiatry Clinical Neurosciences, 18(1), 117-120. doi: 18/1/117 [pii] 10.1176/appi.neuropsych.18.1.117
Simpson, S. W., Baldwin, R. C., Burns, A., & Jackson, A. (2001). Regional cerebral volume measurements in late-life depression: relationship to clinical correlates, neuropsychological impairment and response to treatment. International Journal of Geriatric Psychiatry, 16(5), 469-476.
Steffens, D. C., Otey, E., Alexopoulos, G. S., Butters, M. A., Cuthbert, B., Ganguli, M., . . . Yesavage, J. (2006). Perspectives on depression, mild cognitive impairment, and cognitive decline. Archives of General Psychiatry, 63(2), 130-138. doi: 63/2/130 [pii] 10.1001/archpsyc.63.2.130
Steffens, D. C., Welsh-Bohmer, K. A., Burke, J. R., Plassman, B. L., Beyer, J. L., Gersing, K. R., & Potter, G. G. (2004). Methodology and preliminary results from the neurocognitive outcomes of depression in the elderly study. Journal of Geriatric Psychiatry Neurology, 17(4), 202-211. doi: 17/4/202 [pii] 10.1177/0891988704269819
Von Gunten, A., Giannakopoulos, P., & Duc, R. (2005). Cognitive and demographic determinants of dementia in depressed patients with subjective memory complaints. European Neurology, 54(3), 154-158. doi: 90104 [pii] 10.1159/000090104
Baddeley, A. (2009). Working memory. In A. Baddeley, M. Anderson & M. Eysenck (Eds.), Memory (pp. 41-68). Hove: Psychology Press.
Birch, L. S., & Davidson, K. M. (2007). Specificity of autobiographical memory in depressed older adults and its relationship with working memory and IQ. The British Journal of Clinical Psychology, 46(Pt 2), 175-186. doi: 10.1348/014466506X119944
Chui, W. W., Cheung, E. F., & Lam, L. C. (2011). Neuropsychological profiles and short-term outcome in late-onset depression. International Journal of Geriatric Psychiatry, 26(5), 458-465. doi: 10.1002/gps.2548
Delaloye, C., Baudois, S., de Bilbao, F., Dubois Remund, C., Hofer, F., Lamon, M., . . . Giannakopoulos, P. (2008). Cognitive impairment in late-onset depression. Limited to a decrement in information processing resources? European Neurology, 60(3), 149-154. doi: 000144086 [pii] 10.1159/000144086
Delaloye, C., de Bilbao, F., Moy, G., Baudois, S., Weber, K., Campos, L., & Gold, G. (2009). Neuroanatomical and neuropsychological features of euthymic patients with bipolar disorder. American Journal of Geriatric Psychiatry, 17(12), 1012-1021. doi: 00019442-200912000-00004 [pii] 10.1097/JGP.0b013e3181b7f0e2
Delaloye, C., Moy, G., de Bilbao, F., Baudois, S., Weber, K., Hofer, F., & Gold, G. (2010). Neuroanatomical and neuropsychological features of elderly euthymic depressed patients with early-and-late-onset. Journal of the Neurological Sciences, 299(1-2), 19-23. doi: S0022-510X(10)00413-2 [pii] 10.1016/j.jns.2010.08.046
Elderkin-Thompson, V., Kumar, A., Bilker, W. B., Dunkin, J. J., Mintz, J., Moberg, P. J., ... Gur, R. E. (2003). Neuropsychological deficits among patients with late-onset minor and major depression. Archives of Clinical Neuropsychology, 18(5), 529-549. doi: S0887617703000222 [pii]
Fischer, C., Schweizer, T. A., Atkins, J. H., Bozanovic, R., Norris, M., Herrmann, N., ... Rourke, S. B. (2008). Neurocognitive profiles in older adults with and without major depression. International Journal of Geriatric Psychiatry, 23(8), 851-856. doi: 10.1002/gps.1994
Fiske, A., Wetherell, J. L., & Gatz, M. (2009). Depression in older adults. Annual Review of Clinical Psychology, 5, 363-389. doi: 10.1146/annurev.clinpsy.032408.153621
Foldi, N. S., Brickman, A. M., Schaefer, L. A., & Knutelska, M. E. (2003). Distinct serial position profiles and neuropsychological measures differentiate late life depression from normal aging and Alzheimer’s disease. Psychiatry Research, 120(1), 71-84. doi: S016517810300163X [pii]
Goffaux, P., Phillips, N. A., Sinai, M., & Pushkar, D. (2008). Neurophysiological measures of task-set switching: effects of working memory and aging. The Journals of Gerontology: Series B, Psychology Social Sciences, 63(2), P57-66. doi: 63/2/P57 [pii]
Herrmann, L. L., Goodwin, G. M., & Ebmeier, K. P. (2007). The cognitive neuropsychology of depression in the elderly. Psychological Medicine, 37(12), 1693-1702. doi: S0033291707001134 [pii] 10.1017/S0033291707001134
Lonie, J. A., Tierney, K. M., Herrmann, L. L., Donaghey, C., O’Carroll, R. E., Lee, A., & Ebmeier, K. P. (2009). Dual task performance in early Alzheimer’s disease, amnestic mild cognitive impairment and depression. Psychological Medicine, 39(1), 23-31. doi: S0033291708003346 [pii] 10.1017/S0033291708003346
Luo, L., & Craik, F. I. (2008). Aging and memory: A cognitive approach. Canadian Journal of Psychiatry, 53(6), 346-353.
Mondal, S., Sharma, V. K., Das, S., Goswami, U., & Gandhi, A. (2007). Neuro-cognitive functions in patients of major depression. Indian Journal of Physiology Pharmacology, 51(1), 69-75.
Murray, L. (2002). Cognitive distinctions between depression and early Alzheimer’s disease in the elderly. Aphasiology, 16(4/5/6), 573-585. doi: 10.1080/02687030244000293
Nebes, R. D., Butters, M. A., Houck, P. R., Zmuda, M. D., Aizenstein, H., Pollock, B. G., Reynolds, C. F. (2001). Dual-task performance in depressed geriatric patients. Psychiatry Research, 102(2), 139-151. doi: S0165-1781(01)00244-X [pii]
Nebes, R. D., Butters, M. A., Mulsant, B. H., Pollock, B. G., Zmuda, M. D., Houck, P. R., & Reynolds, C. F. (2000). Decreased working memory and processing speed mediate cognitive impairment in geriatric depression. Psychological Medicine, 30(3), 679-691.
Nebes, R. D., Pollock, B. G., Houck, P. R., Butters, M. A., Mulsant, B. H., Zmuda, M. D., & Reynolds, C. F. (2003). Persistence of cognitive impairment in geriatric patients following antidepressant treatment: A randomized, double-blind clinical trial with nortriptyline and paroxetine. Jounal of Psychiatry Research, 37(2), 99-108. doi: S0022395602000857 [pii]
Nyberg, L., Dahlin, E., Stigsdotter Neely, A., & Bäckman, L. (2009). Neural correlates of variable working memory load across adult age and skill: Dissociative patterns within the fronto-parietal network. Scandinavian Journal of Psychology, 50(1), 41-46. doi: SJOP678 [pii] 10.1111/j.1467-9450.2008.00678.x
O’Brien, J. T., Lloyd, A., McKeith, I., Gholkar, A., & Ferrier, N. (2004). A longitudinal study of hippocampal volume, cortisol levels, and cognition in older depressed subjects. American Journal of Psychiatry, 161(11), 2081-2090. doi: 161/11/2081 [pii] 10.1176/appi.ajp.161.11.2081
Owen, A. M., McMillan, K. M., Laird, A. R., & Bullmore, E. (2005). N-back working memory paradigm: A meta-analysis of normative functional neuroimaging studies. Human Brain Mapping, 25(1), 46-59. doi: 10.1002/hbm.20131
Rozenthal, M., Laks, J., & Egekhardt, E. (2004). Aspectos neuropsicológicos da depressão. Revista de Psiquiatria do Rio Grande do Sul, 26(2), 204-212.
Sair, H. I., Welsh-Bohmer, K. A., Wagner, H. R., & Steffens, D. C. (2006). Ascending digits task as a measure of executive function in geriatric depression. Journal of Neuropsychiatry Clinical Neurosciences, 18(1), 117-120. doi: 18/1/117 [pii] 10.1176/appi.neuropsych.18.1.117
Simpson, S. W., Baldwin, R. C., Burns, A., & Jackson, A. (2001). Regional cerebral volume measurements in late-life depression: relationship to clinical correlates, neuropsychological impairment and response to treatment. International Journal of Geriatric Psychiatry, 16(5), 469-476.
Steffens, D. C., Otey, E., Alexopoulos, G. S., Butters, M. A., Cuthbert, B., Ganguli, M., . . . Yesavage, J. (2006). Perspectives on depression, mild cognitive impairment, and cognitive decline. Archives of General Psychiatry, 63(2), 130-138. doi: 63/2/130 [pii] 10.1001/archpsyc.63.2.130
Steffens, D. C., Welsh-Bohmer, K. A., Burke, J. R., Plassman, B. L., Beyer, J. L., Gersing, K. R., & Potter, G. G. (2004). Methodology and preliminary results from the neurocognitive outcomes of depression in the elderly study. Journal of Geriatric Psychiatry Neurology, 17(4), 202-211. doi: 17/4/202 [pii] 10.1177/0891988704269819
Von Gunten, A., Giannakopoulos, P., & Duc, R. (2005). Cognitive and demographic determinants of dementia in depressed patients with subjective memory complaints. European Neurology, 54(3), 154-158. doi: 90104 [pii] 10.1159/000090104
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2013-07-04
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De Nardi, T., Sanvicente Vieira, B., & Grassi-Oliveira, R. (2013). DÉFICITS NA MEMÓRIA DE TRABALHO EM IDOSOS COM DEPRESSÃO MAIOR:: UMA REVISÃO SISTEMÁTICA. Psicologia: Teoria E Pesquisa, 29(2), 221–228. Recuperado de https://periodicos.unb.br/index.php/revistaptp/article/view/17609
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