Os Correlatos Psiconeuroimunológicos em um Grupo de Homens que Fazem Sexo com Homens com Comportamentos Sexuais de Risco
DOI:
https://doi.org/10.1590/0102.3772e39204.enPalavras-chave:
Psiconeuroimunologia, HIV, Transtornos de humor, Comportamento sexual de risco, Traços de personalidadeResumo
O objetivo deste trabalho é conhecer as correlações que podem ser encontradas entre as medidas psicológicas, neuropsicológicas, neurobiológicas e imunológicas em um grupo de homens que fazem sexo com homens com HIV-1/2 anti-corpos-negativos que se envolvem em comportamentos sexuais de risco. Foram encontradas correlações estatisticamente significativas entre certas variáveis comportamentais, emocionais, de personalidade, neurobiológicas e imunológicas. Destaca-se o circuito de interações entre depressão, estresse, neuroticismo e responsabilidade, que poderia explicar indiretamente o comportamento sexual de risco. Em resumo, há uma relação entre características de personalidade, distúrbios de humor, comportamentos de risco e um perfil de célula T ativado.
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Referências
Agus, D. F., Effendy, E., & Camellia, V. (2019). Screening of anxiety and depression related CD4 count of people living with HIV/AIDS with anti-retroviral in Medan, Indonesia. Open Access Macedonian Journal of Medical Sciences, 7(16), 2590-2594. https://doi.org/10.3889/oamjms.2019.396
Atherton, O. E., Robins, R. W., Rentfrow, P. J., & Lamb, M. E. (2014). Personality correlates of risky health outcomes: Findings from a large internet study. Journal of Research in Personality, 50, 56-60. https://doi.org/10.1016/j.jrp.2014.03.002
Basu, S., & Dasgupta, P. S. (2000). Dopamine, a neurotransmitter, influences the immune system. Journal of Neuroimmunology, 102(2), 113-124. https://doi:10.1016/s0165-5728(99)00176-9
Beck, A. T., & Steer, R. A. (1993). Beck Anxiety Inventory: Manual Psychological Corporation.
Beck, A., Steer, R., & Brown, G. (1996). Manual for the Beck Depression Inventory-II Psychological Corporation.
Beyrer, C., Sullivan, P., Sanchez, J., Baral, S. D., Collins, C., Wirtz, A. L., Altman, D., Trapence, G., & Mayer, K. (2013). The increase in global HIV epidemics in MSM. AIDS (London, England), 27(17), 2665-2678. https://doi.org/10.1097/01.aids.0000432449.30239.fe
Bogg, T., & Roberts, B. W. (2013). The case for conscientiousness: Evidence and implications for a personality trait marker of health and longevity. Annals of Behavioral Medicine: A Publication of the Society of Behavioral Medicine, 45(3), 278-288. https://doi.org/10.1007/s12160-012-9454-6
Carbone, J., Gil, J., Benito, J. M., Navarro, J., Muñóz-Fernández, A., Bartolomé, J., Zabay, J. M., López, F., & Fernández-Cruz, E. (2000). Increased levels of activated subsets of CD4 T cells add to the prognostic value of low CD4 T cell counts in a cohort of HIV-infected drug users. AIDS (London, England), 14(18), 2823-2829. https://doi.org/10.1097/00002030-200012220-00003
Costa, P., & McCrae, R. (1999). Inventario de Personalidad NEO - Revisado [NEO Revised Personality Inventory] TEA.
De la Vega, L., Muñoz, E., Calzado, M. A., Lieb, K., Candelario-Jalil, E., Gschaidmeir, H., Färber, L., Mueller, W., Stratz, T., & Fiebich, B. L. (2005). The 5-HT3 receptor antagonist tropisetron inhibits T cell activation by targeting the calcineurin pathway. Biochemical Pharmacology, 70(3), 369-380.https://doi.org/10.1016/j.bcp.2005.04.031
Drumright, L. N., Patterson, T. L., & Strathdee, S. A. (2006). Club drugs as causal risk factors for HIV acquisition among men who have sex with men: A review. Substance Use & Misuse, 41(10-12), 1551-1601. https://doi.org/10.1080/10826080600847894
Fernandez, J., & Mielgo, M. (2001). Escalas de Apreciación del Estrés: Manual [Stress Evaluation Scales: Guide] TEA.
Gonzalez, S. M., Taborda, N. A., Correa, L. A., Castro, G. A., Hernandez, J. C., Montoya, C. J., & Rugeles, M. T. (2016). Particular activation phenotype of T cells expressing HLA-DR but not CD38 in GALT from HIV-controllers is associated with immune regulation and delayed progression to AIDS. Immunologic Research, 64(3), 765-774. https://doi.org/10.1007/s12026-015-8775-5
Heath, J., Lanoye, A., & Maisto, S. A. (2012). The role of alcohol and substance use in risky sexual behavior among older men who have sex with men: A review and critique of the current literature. AIDS and Behavior, 16(3), 578-589. https://doi.org/10.1007/s10461-011-9921-2
Hoff, C. C., Chakravarty, D., Beougher, S. C., Neilands, T. B., & Darbes, L. A. (2012). Relationship characteristics associated with sexual risk behavior among MSM in committed relationships. AIDS Patient Care And STDs, 26(12), 738-745. https://doi.org/10.1089/apc.2012.0198
Houston, E., Sandfort, T., Dolezal, C., & Carballo-Diéguez, A. (2012). Depressive symptoms among MSM who engage in bareback sex: Does mood matter? AIDS and Behavior, 16(8), 2209-2215. https://doi.org/10.1007/s10461-012-0156-7
Hoyle, R. H., Fejfar, M. C., & Miller, J. D. (2000). Personality and sexual risk taking: A quantitative review. Journal of Personality, 68(6), 1203-1231. https://doi.org/10.1111/1467-6494.00132
Hua, S., Lécuroux, C., Sáez-Cirión, A., Pancino, G., Girault, I., Versmisse, P., Boufassa, F., Taulera, O., Sinet, M., Lambotte, O., & Venet, A. (2014). Potential role for HIV-specific CD38-/HLA-DR+ CD8+ T cells in viral suppression and cytotoxicity in HIV controllers. PloS One, 9(7), e101920. https://doi.org/10.1371/journal.pone.0101920
Kaplan, S. C., Levinson, C. A., Rodebaugh, T. L., Menatti, A., & Weeks, J. W. (2015). Social anxiety and the big five personality traits: The interactive relationship of trust and openness. Cognitive Behaviour Therapy, 44(3), 212-222. https://doi.org/10.1080/16506073.2015.1008032
Kaul, R., Prodger, J., Joag, V., Shannon, B., Yegorov, S., Galiwango, R., & McKinnon, L. (2015). Inflammation and HIV transmission in sub-Saharan Africa. Current HIV/AIDS Reports, 12(2), 216-222. https://doi.org/10.1007/s11904-015-0269-5
Kemeny, M. E. (1994). Psychoneuroimmunology of HIV infection. The Psychiatric Clinics of North America, 17(1), 55-68.
Kipnis, J., Gadani, S., & Derecki, N. C. (2012). Pro-cognitive properties of T cells. Nature Reviews: Immunology, 12(9), 663-669. https://doi.org/10.1038/nri3280
Koblin, B. A., Husnik, M. J., Colfax, G., Huang, Y., Madison, M., Mayer, K., Barresi, P. J., Coates, T. J., Chesney, M. A., & Buchbinder, S. (2006). Risk factors for HIV infection among men who have sex with men. AIDS, 20(5), 731-739. https://doi.org/10.1097/01.aids.0000216374.61442.55
Koelsch, S., Boehlig, A., Hohenadel, M., Nitsche, I., Bauer, K., & Sack, U. (2016). The impact of acute stress on hormones and cytokines and how their recovery is affected by music-evoked positive mood. Scientific Reports, 6(1). https://doi.org/10.1038/srep23008
Koning, F. A., Otto, S. A., Hazenberg, M. D., Dekker, L., Prins, M., Miedema, F., & Schuitemaker, H. (2005). Low-level CD4+ T cell activation is associated with low susceptibility to HIV-1 infection. Journal of Immunology (Baltimore, Md1950): , 175(9), 6117-6122. https://doi.org/10.4049/jimmunol.175.9.6117
Kruse, J. L., Olmstead, R., Helleman, G., Wade, B., Jiang, J., Vasavada, M. M., … Irwin, M. R. (2020). Inflammation and depression treatment response to electroconvulsive therapy: Sex-specific role of Interleukin-8. Brain, Behavior, and Immunity https://doi.org/10.1016/j.bbi.2020.05.069
León-Ponte, M., Ahern, G. P., & O’Connell, P. J. (2007). Serotonin provides an accessory signal to enhance T-cell activation by signaling through the 5-HT7 receptor. Blood, 109(8), 3139-3146. https://doi.org/10.1182/blood-2006-10-052787
Marmor, M., Hertzmark, K., Thomas, S. M., Halkitis, P. N., & Vogler, M. (2006). Resistance to HIV infection. Journal of Urban Health: Bulletin of the New York Academy of Medicine, 83(1), 5-17. https://doi.org/10.1007/s11524-005-9003-8
Mikulak, J., Bozzo, L., Roberto, A., Pontarini, E., Tentorio, P., Hudspeth, K., … Mavilio, D. (2014). Dopamine inhibits the effector functions of activated NK Cells via the upregulation of the D5 receptor. The Journal of Immunology, 193(6), 2792-2800. https://doi.org/doi:10.4049/jimmunol.1401114
Miller, A. H. (2010). Depression and immunity: A role for T cells? Brain, Behavior, and Immunity, 24(1), 1-8. https://doi.org/10.1016/j.bbi.2009.09.009
Nasrollahi, B., Darandegan, K., & Rafatmah, A. (2011). The relationship between personality traits and sexual variety seeking. Procedia - Social and Behavioral Sciences, 30, 1399-1402. https://doi.org/10.1016/j.sbspro.2011.10.272
Ostrosky, P., Gómez, M., Matute, E., Rosselli, M., Ardila, A., & Pineda, D. (2012). Neuropsi: Atención y memoria Manual Moderno.
Passmore, J. A., Jaspan, H. B., & Masson, L. (2016). Genital inflammation, immune activation and risk of sexual HIV acquisition. Current Opinion in HIV and AIDS, 11(2), 156-162. https://doi.org/10.1097/COH.0000000000000232
Resino, S., Seoane, E., Gutiérrez, M. D., León, J. A., & Muñoz-Fernández, M. A. (2006). CD4(+) T-cell immunodeficiency is more dependent on immune activation than viral load in HIV-infected children on highly active antiretroviral therapy. Journal of Acquired Immune Deficiency Syndromes, 42(3), 269-276. https://doi.org/10.1097/01.qai.0000222287.90201.d7
Saha, B., Mondal, A. C., Majumder, J., Basu, S., & Dasgupta, P. S. (2001). Physiological concentrations of dopamine inhibit the proliferation and cytotoxicity of human CD4+ and CD8+ T cells in vitro: A receptor-mediated mechanism. Neuroimmunomodulation, 9(1), 23-33. https://doi.org/10.1159/000049004
Schmitt, D. P. (2004). The Big Five related to risky sexual behaviour across 10 world regions: Differential personality associations of sexual promiscuity and relationship infidelity. European Journal of Personality, 18(4), 301-319. https://doi.org/10.1002/per.520
Schneider, E. M., Ma, X., Stratz, T., Müller, W., Lorenz, I., & Seeling, W. D. (2004). Immunomodulatory function of the 5-HT3 receptor antagonist tropisetron. Scandinavian Journal of Rheumatology, 119(Suppl), 34-40.
Shoptaw, S., & Reback, C. J. (2007). Methamphetamine use and infectious disease-related behaviors in men who have sex with men: Implications for interventions. Addiction, 102(Suppl 1), 130-135. https://doi.org/10.1111/j.1360-0443.2006.01775.x
Søndergaard, S. R., Cozzi Lepri, A., Ullum, H., Wiis, J., Hermann, C. K., Laursen, S. B., Qvist, J., Gerstoft, J., Skinhøj, P., & Pedersen, B. K. (2000). Adrenaline-induced mobilization of T cells in HIV-infected patients. Clinical and Experimental Immunology, 119(1), 115-122. https://doi.org/10.1046/j.1365-2249.2000.01102.x
Steinman L. (2004). Elaborate interactions between the immune and nervous systems. Nature Immunology, 5(6), 575-581. https://doi.org/10.1038/ni1078
Stewart, J. C., Rand, K. L., Muldoon, M. F., & Kamarck, T. W. (2009). A prospective evaluation of the directionality of the depression-inflammation relationship. Brain, Behavior, and Immunity, 23(7), 936-944. https://doi.org/10.1016/j.bbi.2009.04.011
Sutin, A. R., Terracciano, A., Deiana, B., Naitza, S., Ferrucci, L., Uda, M., Schlessinger, D., & Costa Jr, P. T. (2010). High neuroticism and low conscientiousness are associated with interleukin-6. Psychological Medicine, 40(9), 1485-1493. https://doi.org/10.1017/S0033291709992029
Trobst, K. K., Herbst, J. H., Masters, H. L., & Costa, P. T. (2002). Personality pathways to unsafe sex: Personality, condom use, and HIV risk behaviors. Journal of Research in Personality, 36(2), 117-133. https://doi.org/10.1006/jrpe.2001.2334
UNAIDS. (2019). Communities at the center. Defending rights. Breaking barriers. Reaching people with HIV services https://www.unaids.org/sites/default/files/media_asset/2019-global-AIDS-update_en.pdf
Vanable, P. A., Carey, M. P., Brown, J. L., Littlewood, R. A., Bostwick, R., & Blair, D. (2012). What HIV-positive MSM want from sexual risk reduction interventions: Findings from a qualitative study. AIDS and Behavior, 16(3), 554-563. https://doi.org/10.1007/s10461-011-0047-3
Wu, H., Denna, T. H., Storkersen, J. N., & Gerriets, V. A. (2019). Beyond a neurotransmitter: The role of serotonin in inflammation and immunity. Pharmacological Research, 140, 100-114. https://doi.org/10.1016/j.phrs.2018.06.015
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Copyright (c) 2023 Jorge Emiro Restrepo, Ana Claudia Ossa Giraldo, Luis Felipe Higuita Gutierrez, Wildeman Zapata, Gina Paula Cuartas Montoya
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.