Os Correlatos Psiconeuroimunológicos em um Grupo de Homens que Fazem Sexo com Homens com Comportamentos Sexuais de Risco

Autores

DOI:

https://doi.org/10.1590/0102.3772e39204.en

Palavras-chave:

Psiconeuroimunologia, HIV, Transtornos de humor, Comportamento sexual de risco, Traços de personalidade

Resumo

O objetivo deste trabalho é conhecer as correlações que podem ser encontradas entre as medidas psicológicas, neuropsicológicas, neurobiológicas e imunológicas em um grupo de homens que fazem sexo com homens com HIV-1/2 anti-corpos-negativos que se envolvem em comportamentos sexuais de risco. Foram encontradas correlações estatisticamente significativas entre certas variáveis comportamentais, emocionais, de personalidade, neurobiológicas e imunológicas. Destaca-se o circuito de interações entre depressão, estresse, neuroticismo e responsabilidade, que poderia explicar indiretamente o comportamento sexual de risco. Em resumo, há uma relação entre características de personalidade, distúrbios de humor, comportamentos de risco e um perfil de célula T ativado.

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Referências

Agus, D. F., Effendy, E., & Camellia, V. (2019). Screening of anxiety and depression related CD4 count of people living with HIV/AIDS with anti-retroviral in Medan, Indonesia. Open Access Macedonian Journal of Medical Sciences, 7(16), 2590-2594. https://doi.org/10.3889/oamjms.2019.396

Atherton, O. E., Robins, R. W., Rentfrow, P. J., & Lamb, M. E. (2014). Personality correlates of risky health outcomes: Findings from a large internet study. Journal of Research in Personality, 50, 56-60. https://doi.org/10.1016/j.jrp.2014.03.002

Basu, S., & Dasgupta, P. S. (2000). Dopamine, a neurotransmitter, influences the immune system. Journal of Neuroimmunology, 102(2), 113-124. https://doi:10.1016/s0165-5728(99)00176-9

Beck, A. T., & Steer, R. A. (1993). Beck Anxiety Inventory: Manual Psychological Corporation.

Beck, A., Steer, R., & Brown, G. (1996). Manual for the Beck Depression Inventory-II Psychological Corporation.

Beyrer, C., Sullivan, P., Sanchez, J., Baral, S. D., Collins, C., Wirtz, A. L., Altman, D., Trapence, G., & Mayer, K. (2013). The increase in global HIV epidemics in MSM. AIDS (London, England), 27(17), 2665-2678. https://doi.org/10.1097/01.aids.0000432449.30239.fe

Bogg, T., & Roberts, B. W. (2013). The case for conscientiousness: Evidence and implications for a personality trait marker of health and longevity. Annals of Behavioral Medicine: A Publication of the Society of Behavioral Medicine, 45(3), 278-288. https://doi.org/10.1007/s12160-012-9454-6

Carbone, J., Gil, J., Benito, J. M., Navarro, J., Muñóz-Fernández, A., Bartolomé, J., Zabay, J. M., López, F., & Fernández-Cruz, E. (2000). Increased levels of activated subsets of CD4 T cells add to the prognostic value of low CD4 T cell counts in a cohort of HIV-infected drug users. AIDS (London, England), 14(18), 2823-2829. https://doi.org/10.1097/00002030-200012220-00003

Costa, P., & McCrae, R. (1999). Inventario de Personalidad NEO - Revisado [NEO Revised Personality Inventory] TEA.

De la Vega, L., Muñoz, E., Calzado, M. A., Lieb, K., Candelario-Jalil, E., Gschaidmeir, H., Färber, L., Mueller, W., Stratz, T., & Fiebich, B. L. (2005). The 5-HT3 receptor antagonist tropisetron inhibits T cell activation by targeting the calcineurin pathway. Biochemical Pharmacology, 70(3), 369-380.https://doi.org/10.1016/j.bcp.2005.04.031

Drumright, L. N., Patterson, T. L., & Strathdee, S. A. (2006). Club drugs as causal risk factors for HIV acquisition among men who have sex with men: A review. Substance Use & Misuse, 41(10-12), 1551-1601. https://doi.org/10.1080/10826080600847894

Fernandez, J., & Mielgo, M. (2001). Escalas de Apreciación del Estrés: Manual [Stress Evaluation Scales: Guide] TEA.

Gonzalez, S. M., Taborda, N. A., Correa, L. A., Castro, G. A., Hernandez, J. C., Montoya, C. J., & Rugeles, M. T. (2016). Particular activation phenotype of T cells expressing HLA-DR but not CD38 in GALT from HIV-controllers is associated with immune regulation and delayed progression to AIDS. Immunologic Research, 64(3), 765-774. https://doi.org/10.1007/s12026-015-8775-5

Heath, J., Lanoye, A., & Maisto, S. A. (2012). The role of alcohol and substance use in risky sexual behavior among older men who have sex with men: A review and critique of the current literature. AIDS and Behavior, 16(3), 578-589. https://doi.org/10.1007/s10461-011-9921-2

Hoff, C. C., Chakravarty, D., Beougher, S. C., Neilands, T. B., & Darbes, L. A. (2012). Relationship characteristics associated with sexual risk behavior among MSM in committed relationships. AIDS Patient Care And STDs, 26(12), 738-745. https://doi.org/10.1089/apc.2012.0198

Houston, E., Sandfort, T., Dolezal, C., & Carballo-Diéguez, A. (2012). Depressive symptoms among MSM who engage in bareback sex: Does mood matter? AIDS and Behavior, 16(8), 2209-2215. https://doi.org/10.1007/s10461-012-0156-7

Hoyle, R. H., Fejfar, M. C., & Miller, J. D. (2000). Personality and sexual risk taking: A quantitative review. Journal of Personality, 68(6), 1203-1231. https://doi.org/10.1111/1467-6494.00132

Hua, S., Lécuroux, C., Sáez-Cirión, A., Pancino, G., Girault, I., Versmisse, P., Boufassa, F., Taulera, O., Sinet, M., Lambotte, O., & Venet, A. (2014). Potential role for HIV-specific CD38-/HLA-DR+ CD8+ T cells in viral suppression and cytotoxicity in HIV controllers. PloS One, 9(7), e101920. https://doi.org/10.1371/journal.pone.0101920

Kaplan, S. C., Levinson, C. A., Rodebaugh, T. L., Menatti, A., & Weeks, J. W. (2015). Social anxiety and the big five personality traits: The interactive relationship of trust and openness. Cognitive Behaviour Therapy, 44(3), 212-222. https://doi.org/10.1080/16506073.2015.1008032

Kaul, R., Prodger, J., Joag, V., Shannon, B., Yegorov, S., Galiwango, R., & McKinnon, L. (2015). Inflammation and HIV transmission in sub-Saharan Africa. Current HIV/AIDS Reports, 12(2), 216-222. https://doi.org/10.1007/s11904-015-0269-5

Kemeny, M. E. (1994). Psychoneuroimmunology of HIV infection. The Psychiatric Clinics of North America, 17(1), 55-68.

Kipnis, J., Gadani, S., & Derecki, N. C. (2012). Pro-cognitive properties of T cells. Nature Reviews: Immunology, 12(9), 663-669. https://doi.org/10.1038/nri3280

Koblin, B. A., Husnik, M. J., Colfax, G., Huang, Y., Madison, M., Mayer, K., Barresi, P. J., Coates, T. J., Chesney, M. A., & Buchbinder, S. (2006). Risk factors for HIV infection among men who have sex with men. AIDS, 20(5), 731-739. https://doi.org/10.1097/01.aids.0000216374.61442.55

Koelsch, S., Boehlig, A., Hohenadel, M., Nitsche, I., Bauer, K., & Sack, U. (2016). The impact of acute stress on hormones and cytokines and how their recovery is affected by music-evoked positive mood. Scientific Reports, 6(1). https://doi.org/10.1038/srep23008

Koning, F. A., Otto, S. A., Hazenberg, M. D., Dekker, L., Prins, M., Miedema, F., & Schuitemaker, H. (2005). Low-level CD4+ T cell activation is associated with low susceptibility to HIV-1 infection. Journal of Immunology (Baltimore, Md1950): , 175(9), 6117-6122. https://doi.org/10.4049/jimmunol.175.9.6117

Kruse, J. L., Olmstead, R., Helleman, G., Wade, B., Jiang, J., Vasavada, M. M., … Irwin, M. R. (2020). Inflammation and depression treatment response to electroconvulsive therapy: Sex-specific role of Interleukin-8. Brain, Behavior, and Immunity https://doi.org/10.1016/j.bbi.2020.05.069

León-Ponte, M., Ahern, G. P., & O’Connell, P. J. (2007). Serotonin provides an accessory signal to enhance T-cell activation by signaling through the 5-HT7 receptor. Blood, 109(8), 3139-3146. https://doi.org/10.1182/blood-2006-10-052787

Marmor, M., Hertzmark, K., Thomas, S. M., Halkitis, P. N., & Vogler, M. (2006). Resistance to HIV infection. Journal of Urban Health: Bulletin of the New York Academy of Medicine, 83(1), 5-17. https://doi.org/10.1007/s11524-005-9003-8

Mikulak, J., Bozzo, L., Roberto, A., Pontarini, E., Tentorio, P., Hudspeth, K., … Mavilio, D. (2014). Dopamine inhibits the effector functions of activated NK Cells via the upregulation of the D5 receptor. The Journal of Immunology, 193(6), 2792-2800. https://doi.org/doi:10.4049/jimmunol.1401114

Miller, A. H. (2010). Depression and immunity: A role for T cells? Brain, Behavior, and Immunity, 24(1), 1-8. https://doi.org/10.1016/j.bbi.2009.09.009

Nasrollahi, B., Darandegan, K., & Rafatmah, A. (2011). The relationship between personality traits and sexual variety seeking. Procedia - Social and Behavioral Sciences, 30, 1399-1402. https://doi.org/10.1016/j.sbspro.2011.10.272

Ostrosky, P., Gómez, M., Matute, E., Rosselli, M., Ardila, A., & Pineda, D. (2012). Neuropsi: Atención y memoria Manual Moderno.

Passmore, J. A., Jaspan, H. B., & Masson, L. (2016). Genital inflammation, immune activation and risk of sexual HIV acquisition. Current Opinion in HIV and AIDS, 11(2), 156-162. https://doi.org/10.1097/COH.0000000000000232

Resino, S., Seoane, E., Gutiérrez, M. D., León, J. A., & Muñoz-Fernández, M. A. (2006). CD4(+) T-cell immunodeficiency is more dependent on immune activation than viral load in HIV-infected children on highly active antiretroviral therapy. Journal of Acquired Immune Deficiency Syndromes, 42(3), 269-276. https://doi.org/10.1097/01.qai.0000222287.90201.d7

Saha, B., Mondal, A. C., Majumder, J., Basu, S., & Dasgupta, P. S. (2001). Physiological concentrations of dopamine inhibit the proliferation and cytotoxicity of human CD4+ and CD8+ T cells in vitro: A receptor-mediated mechanism. Neuroimmunomodulation, 9(1), 23-33. https://doi.org/10.1159/000049004

Schmitt, D. P. (2004). The Big Five related to risky sexual behaviour across 10 world regions: Differential personality associations of sexual promiscuity and relationship infidelity. European Journal of Personality, 18(4), 301-319. https://doi.org/10.1002/per.520

Schneider, E. M., Ma, X., Stratz, T., Müller, W., Lorenz, I., & Seeling, W. D. (2004). Immunomodulatory function of the 5-HT3 receptor antagonist tropisetron. Scandinavian Journal of Rheumatology, 119(Suppl), 34-40.

Shoptaw, S., & Reback, C. J. (2007). Methamphetamine use and infectious disease-related behaviors in men who have sex with men: Implications for interventions. Addiction, 102(Suppl 1), 130-135. https://doi.org/10.1111/j.1360-0443.2006.01775.x

Søndergaard, S. R., Cozzi Lepri, A., Ullum, H., Wiis, J., Hermann, C. K., Laursen, S. B., Qvist, J., Gerstoft, J., Skinhøj, P., & Pedersen, B. K. (2000). Adrenaline-induced mobilization of T cells in HIV-infected patients. Clinical and Experimental Immunology, 119(1), 115-122. https://doi.org/10.1046/j.1365-2249.2000.01102.x

Steinman L. (2004). Elaborate interactions between the immune and nervous systems. Nature Immunology, 5(6), 575-581. https://doi.org/10.1038/ni1078

Stewart, J. C., Rand, K. L., Muldoon, M. F., & Kamarck, T. W. (2009). A prospective evaluation of the directionality of the depression-inflammation relationship. Brain, Behavior, and Immunity, 23(7), 936-944. https://doi.org/10.1016/j.bbi.2009.04.011

Sutin, A. R., Terracciano, A., Deiana, B., Naitza, S., Ferrucci, L., Uda, M., Schlessinger, D., & Costa Jr, P. T. (2010). High neuroticism and low conscientiousness are associated with interleukin-6. Psychological Medicine, 40(9), 1485-1493. https://doi.org/10.1017/S0033291709992029

Trobst, K. K., Herbst, J. H., Masters, H. L., & Costa, P. T. (2002). Personality pathways to unsafe sex: Personality, condom use, and HIV risk behaviors. Journal of Research in Personality, 36(2), 117-133. https://doi.org/10.1006/jrpe.2001.2334

UNAIDS. (2019). Communities at the center. Defending rights. Breaking barriers. Reaching people with HIV services https://www.unaids.org/sites/default/files/media_asset/2019-global-AIDS-update_en.pdf

Vanable, P. A., Carey, M. P., Brown, J. L., Littlewood, R. A., Bostwick, R., & Blair, D. (2012). What HIV-positive MSM want from sexual risk reduction interventions: Findings from a qualitative study. AIDS and Behavior, 16(3), 554-563. https://doi.org/10.1007/s10461-011-0047-3

Wu, H., Denna, T. H., Storkersen, J. N., & Gerriets, V. A. (2019). Beyond a neurotransmitter: The role of serotonin in inflammation and immunity. Pharmacological Research, 140, 100-114. https://doi.org/10.1016/j.phrs.2018.06.015

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Publicado

2023-07-10

Como Citar

Restrepo, J. E., Ossa Giraldo, A. C., Higuita Gutierrez, L. F., Zapata, W., & Cuartas Montoya, G. P. (2023). Os Correlatos Psiconeuroimunológicos em um Grupo de Homens que Fazem Sexo com Homens com Comportamentos Sexuais de Risco. Psicologia: Teoria E Pesquisa, 39. https://doi.org/10.1590/0102.3772e39204.en

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Estudos Empíricos