Avaliação de Prejuízo Cognitivo em Sobreviventes de Câncer de Mama: Estudo Transversal
Chemobrain em Câncer de Mama
DOI:
https://doi.org/10.1590/0102.3772e38218.ptPalavras-chave:
Disfunção cognitiva, Sobreviventes, Câncer de mama, Psico-OncologiaResumo
Estudo prospectivo e transversal, para determinar a prevalência de prejuízo cognitivo decorrente da quimioterapia e explorar fatores preditores e mediadores em sobreviventes de câncer de mama. Utilizou-se o Termômetro de Distress, Escala de Ansiedade e Depressão, Functional Assessment of Chronic Illness Therapy-General e Cognitive Function. As sobreviventes (N = 62) reportaram uma alta prevalência de distress (46,8%) e de ansiedade (24,2%), com baixos escores nas subescalas déficit cognitivo e habilidades cognitivas percebidos. O funcionamento cognitivo esteve associado à idade (B = 1,42; p = 0,002), atuação profissional (B = -23,12; p = 0,004), depressão (B = -5,43; p = 0,001) e qualidade de vida (B = 1,24; p = 0,001). Prejuízo cognitivo deve ser considerado no serviço de Psico-Oncologia
Downloads
Referências
Ahles, T. A., & Hurria, A. (2018). Cognition and cancer: conceptual and methodological issues and future directions. Psycho-Oncology, 27(1), 3-9. https://doi.org/10.1002/pon.4564
Arnold, B. J., Eremenco, S., Chang, C. H., Odom, L., Ribaudo, J., & Cella, D. (2000). Development of a single Portuguese language version of the functional assessment of cancer therapy general (FACT-G) scale. Quality of Life Research, 9(3), 316.
Avis, N. E., Levine, B. J., Case, L. D., Naftalis, E. Z., & Zee, K. J. van. (2015). Trajectories of depressive symptoms following breast cancer diagnosis. Cancer Epidemiology, Biomarkers & Prevention”¯: A Publication of the American Association for Cancer Research, 24(11), 1789-1795. https://doi.org/10.1158/1055-9965.EPI-15-0327
Bergerot, C. D., & Araujo, T. C. C. F. (2014). Assessment of distress and quality of life of cancer patients over the course of chemotherapy. Investigacion Y Educacion En Enfermeria, 32(2), 216-224. https://doi.org/10.1590/S0120-53072014000200004
Botega, N. J., Bio, M. R., Zomignani, M. A., Garcia, C., Jr., & Pereira, W. A. B. (1995). Mood disorders among medical in-patients: a validation study of the hospital anxiety and depression scale (HAD). Revista de Saúde Pública, 29(5), 355-363. https://doi.org/10.1590/S0034-89101995000500004
Boykoff, N., Moieni, M., & Subramanian, S. K. (2009). Confronting chemobrain: An in-depth look at survivors’ reports of impact on work, social networks, and health care response. Journal of Cancer Survivorship, 3(4), 223-232. https://doi.org/10.1007/s11764-009-0098-x
Bray, V. J., Dhillon, H. M., Bell, M. L., Kabourakis, M., Fiero, M. H., Yip, D., ... Vardy, J. L. (2017). Evaluation of a web-based cognitive rehabilitation program in cancer survivors reporting cognitive symptoms after chemotherapy. Journal of Clinical Oncology, 35(2), 217-225. https://doi.org/10.1200/JCO.2016.67.8201
Brucker, P. S., Yost, K., Cashy, J., Webster, K., & Cella, D. (2005). General population and cancer patient norms for the Functional Assessment of Cancer Therapy-General (FACT-G). Evaluation & The Health Professions, 28(2), 192-211. https://doi.org/10.1177/0163278705275341
Brunault, P., Champagne, A. L., Huguet, G., Suzanne, I., Senon, J. L., Body, G., ... Camus, V. (2016). Major depressive disorder, personality disorders, and coping strategies are independent risk factors for lower quality of life in non-metastatic breast cancer patients. Psycho-Oncology, 25(5), 513-520. https://doi.org/10.1002/pon.3947
Bultz, B. D., Groff, S. L., Fitch, M., Blais, M. C., Howes, J., Levy, K., & Mayer, C. (2011). Implementing screening for distress, the 6th vital sign: a Canadian strategy for changing practice. Psycho-Oncology, 20(5), 463-469. https://doi.org/10.1002/pon.1932
DeRuiter, M. B., Reneman, L., Boogerd,W., Veltman, D. J., Dam, F. S. van, Nederveen, A. J., ... Schagen, S. B. (2011). Cerebral hyporesponsiveness and cognitive impairment 10 years after chemotherapy for breast cancer. Human Brain Mapping, 32(8), 1206-1219. https://doi.org/10.1002/hbm.21102
Decat, C. S., Laros, J. A., & Araujo, T. C. C. F. (2009). Distress Thermometer: validation of a brief screening instrument to detect distress in oncology patients. Psico-USF, 14(3), 253-260. https://doi.org/10.1590/S1413-82712009000300002
Fallowfield, L., & Jenkins, V. (2015). Psychosocial/Survivorship issues in breast cancer: are we doing better? Journal of the National Cancer Institute, 107(1), 335. https://doi.org/10.1093/jnci/dju335
Ferguson, R. J., McDonald, B. C., Rocque, M. A., Furstenberg, C. T., Horrigan, S., Ahles, T. A., & Saykin, A. J. (2012). Development of CBT for chemotherapy-related cognitive change: Results of a waitlist control trial. Psycho-Oncology, 21(2), 176-186. https://doi.org/10.1002/pon.1878
Hartman, S. J., Nelson, S. H., Myers, E., Natarajan, L., Sears, D. D., Palmer, B. W. ... Patterson, R. E. (2018). Randomized controlled trial of increasing physical activity on objectively measured and self-reported cognitive functioning among breast cancer survivors: The memory & motion study. Cancer, 124(1), 192-202. https://doi.org/ 10.1002/cncr.30987
Hayes, A. F. (2013). Introduction to mediation, moderation, and conditional process analysis. New York: Guilford Press.
Hurria, A., Somlo, G., & Ahles, T. (2007) Renaming "chemobrain". Cancer Investigation, 25, 373”“377. https://doi.org/10.1080/07357900701506672
International Agency for Research on Cancer (2018). GLOBOCAN 2018: Estimated cancer incidence, mortality and prevalence worldwide in 2018. Recuperado em janeiro 13, 2020, de https://www.uicc.org/news/new-global-cancer-data-globocan-2018
Janelsins, M. C., Heckler, C. E., Peppone, L. J., Kamen, C., Mustian, K. M., Mohile, S. G., ... Morrow, G. R. (2017). Cognitive complaints in survivors of breast cancer after chemotherapy compared with age-matched controls: An analysis from a nationwide, multicenter, prospective longitudinal study. Journal of Clinical Oncology, 35(5), 506-514. https://doi.org/10.1200/JCO.2016.68.5826
Krebber, A. M. H., Buffart, L. M., Kleijn, G., Riepma, I. C., DeBree, R., Leemans, C. R., ... Verdonck-de Leeuw, I. M. (2014). Prevalence of depression in cancer patients: a meta-analysis of diagnostic interviews and self-report instruments. Psycho-Oncology, 23(2), 121-130. https://doi.org/10.1002/pon.3409
Lange, M., Joly, F., Vardy, J., Ahles, T., Dubois, M., Tron, L., … Castel, H. (2019). Cancer-related cognitive impairment: An update on state of the art, detection, and management strategies in cancer survivors. Annals of Oncology, 30(12), 1925-1940. https://doi.org/10.1093/annonc/mdz410
Myers, J. S., Pierce, J., & Pazdernik, T. (2008). Neurotoxicology of chemotherapy in relation to cytokine release, the blood-brain barrier and cognitive impairment. Oncology Nursing Forum, 35(6), 916-920. https://doi.org/10.1188/08.ONF.916-920
Mitchell, A. J., Ferguson, D. W., Gill, J., Paul, J., & Symonds, P. (2013). Depression and anxiety in long-term cancer survivors compared with spouses and healthy controls: A systematic review and meta-analysis. Lancet Oncology, 14(8), 721-732. https://doi.org/10.1016/S1470-2045(13)70244-4
Morean, D. F., & Cherney, L. R. (2016). Screening for Cognitive Impairment Associated with Chemotherapy for Breast Cancer. Current Breast Cancer Reports, 8, 151-157. https://doi.org/10.1007/s12609-016-0219-2
Neuwelt, E. A., Bauer, B., Fahlke, C., Fricker, G., Iadecola, C., Janigro, D., ... Drewes, L. R. (2011). Engaging neuroscience to advance translational research in brain barrier biology. Nature Reviews Neuroscience, 12(3), 169-182. https://doi.org/10.1038/nrn2995
Ongnok, B., Chattipakorn, N., & Chattipakorn, S. C. (2019). Doxorubicin and cisplatin induced cognitive impairment: The possible mechanisms and interventions. Experimental Neurology, 324, 113118. https://doi.org/10.1016/j.expneurol.2019.113118
Runowicz, C. D., Leach, C. R., Henry, N. L., Henry, K. S., Mackey, H. T., Cowens-Alvarado, R. L., ... Ganz, P. A. (2016). American Cancer Society/American Society of Clinical Oncology Breast Cancer Survivorship Care Guideline. CA: A Cancer Journal for Clinicians, 66(1), 43-73. https://doi.org/10.3322/caac.21319
Saboonchi, F., Petersson, L. M., Wennman-Larsen, A., Alexanderson, K., & Vaez, M. (2015). Trajectories of anxiety among women with breast cancer: A proxy for adjustment from acute to transitional survivorship. Journal of Psychosocial Oncology, 33(6), 603-619. https://doi.org/10.1080/07347332.2015.1082165
Siegel, R. L., Miller, K. D., Jemal, A. (2019). Cancer statistics, 2019. CA: A Cancer Journal for Clinicians, 69(1), 7-34. https://doi.org/10.3322/caac.21551
Small, B. J., Jim, H. S. L., Eisel, S. L., Jacobsen, P. B., Scott, S. B. (2019). Cognitive performance of breast cancer survivors in daily life: Role of fatigue and depressed mood. Psycho-oncology, 28(11), 2174-2180. https://doi.org/10.1002/pon.5203
Vardy, J. L., Stouten-Kemperman, M. M., Pond, G., Booth, C. M., Rourke, S. B., Dhillon, H. M., ... Tannock, I. F. (2017). A mechanistic cohort study evaluating cognitive impairment in women treated for breast cancer. Brain Imaging and Behavior, 1-12. https://doi.org/10.1007/s11682-017-9728-5
Wagner, L. I., Sweet, J., Butt, Z., Lai, J., & Cella, D. (2009). Measuring Patient Self-Reported Cognitive Function: Development of the Functional Assessment of Cancer Therapy”“Cognitive Function Instrument. The Journal of Supportive Oncology, 7(6), W32-W39.
Wang, X.-M., Walitt, B., Saligan, L., Tiwari, A. F., Cheung, C. W., & Zhang, Z.-J. (2015). Chemobrain: A critical review and causal hypothesis of link between cytokines and epigenetic reprogramming associated with chemotherapy. Cytokine, 72(1), 86”“96. https://doi.org/10.1016/j.cyto.2014.12.006
Wefel, J. S., Saleeba, A. K., Buzdar, A. U., & Meyers, C. A. (2010). Acute and late onset cognitive dysfunction associated with chemotherapy in women with breast cancer. Cancer, 116(14), 3348-3356. https://doi.org/10.1002/cncr.25098
World Health Organization (2016). Breast cancer: Prevention and control. Recuperado em novembro 15, 2017, de http://www.who.int/cancer/detection/breastcancer/en/
Zimmer, P., Baumann, F. T., Oberste, M., Wright, P., Garthe, A., Schenk, A., ... Wolf, F. (2016). Effects of exercise interventions and physical activity behavior on cancer related cognitive impairments: A systematic review. BioMed Research International, 2016, 1820954. https://doi.org/ 10.1155/2016/1820954
Downloads
Publicado
Como Citar
Edição
Seção
Licença
Copyright (c) 2022 Renata Nunes Pedras, Maria Fernanda Marcusso Manhães, Aline Millani Carneiro, Getúlio Yuzo Okuma, Simone Elias, Edvane Birelo Lopes De Domenico, Cristiane Decat Bergerot
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.