MODELAGEM HÍBRIDA EM TRÊS ESCALAS PARA O CRESCIMENTO TUMORAL

Authors

  • Heber L. Rocha LNCC
  • Regina C. Almeida LNCC
  • Anna Claudia M. Resende LNCC
  • Ernesto A. B. F. Lima ICES

DOI:

https://doi.org/10.26512/ripe.v2i11.21267

Keywords:

Crescimento tumoral, Modelo h´Ä±brido, Reações moleculares

Abstract

O crescimento tumoral é resultado de uma série de complexos fenômenos que ocorrem em múltiplas escalas de tempo e espaço. Neste trabalho, desenvolvemos um modelo híbrido que representa fenômenos do crescimento tumoral avascular que ocorrem nas escalas tecidual, celular e sub-celular. A dispersão de nutrientes e de fatores de crescimento ocorrem na escala do tecido. Na escala da célula, destacam-se as interações mecânicas entre células e entre os componentes do microambiente. Na escala sub-celular ocorre uma variedade de cascatas de reações moleculares que regulam as atividades celulares. Eventos que ocorrem em distintas escalas se inter-relacionam, de modo que o entendimento destes mecanismos é fundamental para a compreensão da doença e para o desenvolvimento de terapias. Experimentos computacionais são realizados para demonstrar o potencial uso da metodologia desenvolvida.

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Published

2017-01-10

How to Cite

Rocha, H. L., Almeida, R. C., Resende, A. C. M., & Lima, E. A. B. F. (2017). MODELAGEM HÍBRIDA EM TRÊS ESCALAS PARA O CRESCIMENTO TUMORAL. Revista Interdisciplinar De Pesquisa Em Engenharia, 2(11), 61–74. https://doi.org/10.26512/ripe.v2i11.21267

Issue

Vol. 2 No. 11 (2016): COMPUTATIONAL METHODS FOR IMAGE, MODELING OF CANCER AND THERMAL SCIENCE

Section

Artigos

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