Reflexões bioéticas sobre a “desextinção” de espécies

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DOI:

https://doi.org/10.26512/rbb.v16.2020.34453

Palavras-chave:

Desextinção. Bioética. Clonagem animal. Engenharia genética. Translocação de espécies.

Resumo

Uma ideia sugerida nos últimos anos para conservar a biodiversidade e recuperar ecossistemas é a desextinção, que se baseia no uso de abordagens moleculares para trazer organismos extintos e/ou sua função novamente. Três abordagens foram sugeridas para a desextinção, são elas reprodução seletiva, clonagem e engenharia genética, todas consideradas problemáticas e sem um benefício concreto. Consequentemente, diversas implicações bioéticas foram apontadas acerca da implementação da desextinção. Este artigo teve por objetivo revisar a literatura sobre o assunto a fim de identificar as principais questões bioéticas levantadas por autores. Foram identificadas diversas questões bioéticas, dentre as mais citadas a ausência de ecossistemas originais de espécies extintas, redução da sensibilidade governamental quanto às atuais práticas de conservação e violações do bem-estar dos indivíduos envolvidos. Consideramos que há muitos assuntos a serem debatidos e que os principais fatores limitantes da desextinção são os aspectos evolutivos que ela não devolverá à natureza, levando a gastos desnecessários e diversos riscos envolvidos.

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Referências

Abeli T, Dalrymple S, Godefroid S, Mondoni A, Müller JV, Rossi G, Orsenigo S. Ex situ collections and their potential for the restoration of extinct plants. Conservation Biology 2020; 34(2): 303-313.

Abrahão CR. Estratégias para o manejo do teiú (Salvator merianae Duméril & Bi-bron, 1839), um lagarto invasor no arquipélago de Fernando de Noronha, PE, Brasil (tese). São Paulo: Universidade de São Paulo; 2019.

Adams WM. Geographies of conservation I: De-extinction and precision conservati-on. Progress in Human Geography 2017; 41(4): 534-545.

Amills M, Jiménez N, Jordana J, Riccardi A, Fernández-Arias A, Guiral J, Bouzat JL, Folch J, Sanchez A. Low diversity in the major histocompatibility complex class II DRB1 gene of the Spanish ibex, Capra pyrenaica. Heredity 2004; 93(3): 266-272.

Babcock HM. The genie is out of the de-extinction bottle. Virginia Environmental Law Journal 2019; 37(3): 170-206.

Banks PB, Hochuli DF. Extinction, de-extinction and conservation: a dangerous mix of ideas. Australian Zoologist 2017; 38(3): 390-394.

Barasc H, Ferchaud S, Mary N, Cucchi MA, Lucena, AN, Letron IR, Calgaro A, Bonnet N, Dudez AM, Yerle M, Ducos, A, Pinton, A. Cytogenetic analysis of somatic and germinal cells from 38, XX/38, XY phenotypically normal boars. Theriogenology 2014; 81(2): 368-372.

Bellard C, Cassey P, Blackburn TM. Alien species as a driver of recent extinctions. Biology Letters 2016; 12(2): 20150623.

Bennett JR, Maloney RF, Steeves TE, Brazill-Boast J, Possingham HP, Seddon PJ. Spending limited resources on de-extinction could lead to net biodiversity loss. Nature Ecology & Evolution 2017; 1(4): 0053.

Blockstein DE. We can’t bring back the passenger pigeon: the ethics of deception around de-extinction. Ethics, Policy & Environment 2017; 20(1): 33-37.

Brisman A, South N. A criminology of extinction: biodiversity, extreme consump-tion and the vanity of species resurrection. European Journal of Criminology 2020; 17(6): 918-935.

Browning H. Won’t somebody please think of the mammoths? De-extinction and animal welfare. Journal of Agricultural and Environmental Ethics 2018; 31(6): 785-803.

Brusatte S. Ascensão e queda dos dinossauros: uma nova história de um mundo per-dido. Rio de Janeiro: Record; 2019.

Camacho AE. Going the way of the dodo: de-extinction, dualisms, and reframing con-servation. Washington UL Review 2014; 92: 849.

Campagna C, Guevara D, Le Boeuf B. De‐scenting extinction: the promise of de‐extinction may hasten continuing extinctions. Hastings Center Report 2017; 47: S48-S53.

Carlin NF, Wurman I, Zakim T. How to permit your mammoth: some legal implica-tions of de-extinction. Stan. Envtl. LJ 2013; 33: 3.

Ceballos G, Ehrlich PR, Dirzo R. Biological annihilation via the ongoing sixth mass extinction signaled by vertebrate population losses and declines. Proceedings of the National Academy of Sciences 2017; 114(30): E6089-E6096.

Chavatte-Palmer P, Camous S, Jammes H, Le Cleac’h N, Guillomot M, Lee RSF. Placental perturbations induce the developmental abnormalities often observed in bovi-ne somatic cell nuclear transfer. Placenta 2012; 33: S99-S104.

Church GM, Regis E. Regenesis: how synthetic biology will reinvent nature and ourselves. Basic Books; 2014.

Cohen S. The ethics of de-extinction. NanoEthics 2014; 8(2): 165-178.

Cottrell S, Jensen JL, Peck SL. Resuscitation and resurrection: the ethics of cloning cheetahs, mammoths, and neanderthals. Life Sciences, Society and Policy 2014; 10(1): 1-17.

Cowie RH, Bouchet P, Fontaine B. The Sixth Mass Extinction: fact, fiction or spe-cula-tion?. Biological Reviews 2022; 97(2): 640-663.

Davis CN, Moran MD. An argument supporting de-extinction and a call for field research. Frontiers of Biogeography 2016; 8(3).

Delord J. The nature of extinction. Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 2007; 38(3): 656-667.

Denner J. Risk of pathogenic virus transmission by somatic cell nuclear transfer: implications for xenotransplantation. Biology of Reproduction 2022; 107(3): 717-722.

Desalle R, Amato G. Conservation genetics, precision conservation, and de‐extinction. Hastings Center Report 2017; 47: S18-S23.

Diehm C. De-extinction and deep questions about species conservation. Ethics, Policy & Environment 2017; 20(1): 25-28.

Donlan J. De-extinction in a crisis discipline. Frontiers of Biogeography 2014; 6(1).

Dooren TV, Rose DB. Keeping faith with the dead: mourning and de-extinction. Australian Zoologist 2017; 38(3): 375-378.

Dorado G, Luque F, Pascual P, Jiménez I, Sánchez-Cañete FJS, Raya P, Sáiz J, Sánchez A, Rosales TE, Vásquez VF, Hernández P. Bioarchaeology to bring back scents from extinct plants-review. Archaeobios 2019; (13): 66-75.

Elewa AMT. Mass extinction. Berlim: Springer; 2008: 1-4.

Erwin DH. The end and the beginning: recoveries from mass extinctions. Trends in Ecology & Evolution 1998; 13(9): 344-349.

Feye KM, Smith JS, Sebbag L, Hohman AE, Acharya S. Veterinary considerations for the theoretical resurrection of extinct species. J Vet Sci Ani Husb 2018; 6(3): 306.

Fletcher AL. Mendel's ark: Conservation genetics and the future of extinction. Re-view of Policy Research 2008; 25(6): 598-607.

Fletcher A. Genuine fakes: cloning extinct species as science and spectacle. Politics and the Life Sciences 2010; 29(1): 48-60.

Fletcher AL. Mammoths, museums, and molecules: a de-extinction icon emerges. De-Extinction and the Genomics Revolution: Life on Demand 2020: 45-61.

Folch J, Cocero MJ, Chesné P, Alabart JL, Domínguez V, Cognié Y, Roche A, Fer-nández-Árias A, Martí JA, Sanchéz P, Echegoyen E, Beckers JF, Bonastre AS, Vignon X. First birth of an animal from an extinct subspecies (Capra pyrenaica pyrenaica) by cloning. Theriogenology 2009; 71(6): 1026-1034.

Friese C, Marris C. Making de-extinction mundane? PLoS Biology 2014; 12(3).

Funk C, Hefferon M. Public views of gene editing for babies depend on how it would be used. Washington, DC: Pew Research Center; 2018.

Gamborg C (2014). What’s so special about reconstructing a mammoth? Ethics of breending and biotechnology in re-creating extinct species. In: Oksanen M, Siipi H. The ethics of animal re-creation and modification: reviving, rewilding, restoring. London: Palgrave Macmillan UK; 2014: 60-76.

Genovesi P, Simberloff D. “De-extinction” in conservation: assessing risks of relea-sing “resurrected” species. Journal for Nature Conservation 2020; 125838.

Gouveia C, Huyser C, Egli D, Pepper MS. Lessons learned from somatic cell nucle-ar transfer. International Journal of Molecular Sciences 2020; 21(7): 2314.

Graipel ME, Cherem JJ, Bogoni JA, Pires JSR. Características associadas ao risco de extinção nos mamíferos terrestres da Mata Atlântica. Oecologia Australis 2016; 20(1).

Greely HT. Is de‐extinction special?. Hastings Center Report 2017; 47: S30-S36.

Harley EH, Knight MH, Lardner C, Wooding B, Gregor M. The Quagga project: pro-gress over 20 years of selective breeding. South African Journal of Wildlife Research 2019; 39(2): 155-163.

Hung CM, Shaner PJL, Zink RM, Liu WC, Chu TC, Huang WS, Li SH. Drastic population fluctuations explain the rapid extinction of the passenger pigeon. Procee-dings of the National Academy of Sciences 2014; 111(29): 10636-10641.

Iacona G, Maloney RF, Chades I, Bennett JR, Seddon PJ, Possingham HP. Prioriti-zing revived species: what are the conservation management implications of de‐extinction?. Functional Ecology 2017; 31(5): 1041-1048.

Jones KE. From dinosaurs to dodos: who could and should we de-extinct?. Frontiers of Biogeography 2014; 6(1).

Jørgensen D. Reintroduction and de-extinction. BioScience 2013; 63(9): 719-720.

Kasperbauer TJ. Should we bring back the passenger pigeon? The ethics of de-extinction. Ethics, Policy & Environment 2017; 20(1): 1-14.

Kolbert E. A sexta extinção: uma história não natural. Rio de Janeiro: Intrínseca; 2015.

Kumar S. Extinction need not be forever. Nature 2012; 492(7427): 9.

Lean CH. Why wake the dead? Identity and de-extinction. Journal of Agricultural and Environmental Ethics 2020; 33(3-6): 571-589.

Liinamaa S. Of thesis bringing back to life a mammoth in the real world Jurassic Park. Public Understanding of Science 2020; 25(1): 31-44.

Lindquist, MA. Aesthetics at the intersection of the species problem and de-extinction Technology Environmental Values 2020.

Loi P, Wakayama T, Saragustry J, Fulka Jr J, Ptak G. Biological time machines: a rea-listic approach for cloning an extinct mammal. Endangered Species Research 2011; 14(3): 227-233.

Lowe M. Implications of species-as-individuals: kinds, essentialism, induction, de-extinction (tese). Connecticut: University of Connecticut Graduate School; 2014.

Malakar D, Akshey Y, De A, Dutta R. Somatic cell cloning technique for production of cloned animals and its application–a review. Indian Journal of Animal Health 2016; 55(1): 1-20.

Martinelli L, Oksanen M, Siipi H. De-extinction: a novel and remarkable case of bio-objectification. Croatian Medical Journal 2014; 55(4): 423.

Mason C. The unnaturalness objection to de-extinction: a critical evaluation. Animal Studies Journal 2017; 6(1): 40-60.

McCauley DJ, Hardesty‐Moore M, Halpern BS, Young HS. A mammoth underta-king: harnessing insight from functional ecology to shape de‐extinction priority setting. Functional Ecology 2017; 31(5): 1003-1011.

Meine C. De‐extinction and the community of being. Hastings Center Report 2017; 47: S9-S17.

Minteer B. Is it right to reverse extinction?. Nature 2014; 509(7500): 261-261.

Minteer BA. The perils of de-extinction. Minding Nature 2015; 8(1): 11-17.

Mizrahi M. How to play the “playing God” card. Science and Engineering Ethics 2020; 1-17.

Montoya FA, Pera JP, Guiral J. El programa de recuperación del bucardo, la cabra montés de los Pirineos. Naturaleza Aragonesa 1997; 1: 51-55.

Myers KM, Davis M. Mechanisms of fear extinction. Molecular Psychiatry 2007; 12(2): 120-150.

Niayale R, Cui Y, Adzitey F. Male hybrid sterility in the cattle-yak and other bovi-nes: A review. Biology of Reproduction 2021; 104(3): 495-507.

Novak BJ. De-extinction. Genes 2018; 9(11): 548.

Ogden LE. Extinction is forever… or is it?. BioScience 2014; 64(6): 469-475.

Ogura A, Inoue K, Wakayama T. Recent advancements in cloning by somatic cell nu-clear transfer. Philosophical Transactions of the Royal Society B: Biological Scien-ces 2013; 368(1609): 20110329.

Oksanen M, Vuorisalo T. De-extinct species as wildlife. Journal for Human-Animal Studies 2017; 3: 4-27.

Okuno E. Frankenstein's Mammoth: anticipating the global legal framework for de-extinction. Ecology LQ 2016; 43: 581.

Osborne PE, Seddon PJ. Selecting suitable habitats for reintroductions: variation, change and the role of species distribution modelling. Reintroduction Biology: Integra-ting Science and Management 2012; 1.

Otto SP. Adaptation, speciation and extinction in the Anthropocene. Proceedings of the Royal Society B 2018; 285(1891): 20182047.

Palkopoulou E, Mallick S, Skoglund P, Enk J, Rohland N, Li H, Omrak A, Vartan-yan S, Poinar H, Götherström A, Dalén L, Reich D. Complete genomes reveal signatu-res of demographic and genetic declines in the woolly mammoth. Current Biology 2015; 25(10): 1395-1400.

Peers MJ, Thornton DH, Majchrzak YN, Bastille-Rousseau G, Murray DL. De-extinction potential under climate change: extensive mismatch between historic and future habitat suitability for three candidate birds. Biological Conservation 2016; 197: 164-170.

Pereira AF, Borges AA, Santos MVO, Lira, GPO. Uso da clonagem por transferên-cia nuclear na conservação e multiplicação de mamíferos silvestres. Revista Brasileira de Reprodução Animal 2019; 43(2): 242-247.

Pimm SL, Raven P. Extinction by numbers. Nature 2000; 403(6772): 843-845.

Pina-Aguilar RE, Lopez-Saucedo J, Sheffield R, Ruiz-Galaz LI, Barroso-Padilla JJ, Gutiérrez-Gutiérrez A. Revival of extinct species using nuclear transfer: hope for the mammoth, true for the Pyrenean ibex, but is it time for “conservation cloning”? Cloning and Stem Cells 2009; 11(3): 341-346.

Pyron RA, Pennell M. Macroevolutionary perspectives on Anthropocene extinction. Biological Conservation 2022; 274: 109733.

Richmond DJ, Sinding MHS, Gilbert MTP. The potential and pitfalls of de‐extinction. Zoologica Scripta 2016; 45: 22-36.

Robert A, Thévenin C, Princé K, Sarrazin F, Clavel J. De‐extinction and evolution. Functional Ecology 2017; 31(5): 1021-1031.

Rohwer Y, Marris E. An analysis of potential ethical justifications for mammoth de-extinction and a call for empirical research. Ethics, Policy & Environment 2018; 21(1): 127-142.

Rumsey F, Stroh P. Will de-extinction be forever? Lessons from the re-introductions of Bromus interruptus (Hack.) Druce. Journal for Nature Conservation 2020; 125835.

Quilodrán CS, Currat M, Montoya‐Burgos JI. Effect of hybridization with genome exclusion on extinction risk. Conservation Biology 2018; 32(5): 1139-1149.

Sanches MA. Brincando de Deus: bioética e as marcas sociais da genética. Revista Brasileira de Bioética 2008; 4(1-2): 118-119.

Sandler R. The ethics of reviving long extinct species. Conservation Biology 2014; 28(2): 354-360.

Sandler R. De-extinction: costs, benefits and ethics. Nature Ecology & Evolution 2017; 1(4): 0105.

Saulsberry A. Should extinction be forever. Vanderbilt Undergraduate Research Journal 2015; 10.

Schlebusch CM. Genomics: testing the limits of de-extinction. Current Biology 2022; 32(7): R324-R327.

Seddon PJ, Griffiths CJ, Soorae PS, Armstrong DP. Reversing defaunation: restoring species in a changing world. Science 2014; 345(6195): 406-412.

Seddon PJ a. The ecology of de-extinction. Functional Ecology 2017; 31(5): 992-995.

Seddon PJ b. De-extinction and barriers to the application of new conservation to-ols. Hastings Center Report 2017; 47: S5-S8.

Seddon PJ, King M. Creating proxies of extinct species: the bioethics of de-extinction. Emerging Topics in Life Sciences 2019; 3(6): 731-735.

Segar ST, Fayle TM, Srivastava DS, Lewinsohn TM, Lewis OT, Novotny V, Kit-ching RL, Maunsell SC. The role of evolution in shaping ecological networks. Trends in Ecology & Evolution 2020; 35(5): 454-466.

Segre M. Definição de bioética e sua relação com a ética, deontologia e diceologia. Bioética 1995; 3.

Selbach C, Seddon PJ, Poulin R. Parasites lost: neglecting a crucial element in de-extinction. Trends in Parasitology 2018; 34(1): 9-11.

Shapiro B. Mammoth 2.0: will genome engineering resurrect extinct species?. Ge-nome Biology 2015; 16(1): 1-3.

Shapiro B. Pathways to de‐extinction: how close can we get to resurrection of an extinct species?. Functional Ecology 2017; 31(5): 996-1002.

Sherkow JS, Greely HT. What if extinction is not forever? Science 2013; 340(6128): 32-33.

Siipi H, Finkelman L. The extinction and de-extinction of species. Philosophy & Technology 2017; 30: 427-441.

Slater MH, Clatterbuck H. A pragmatic approach to the possibility of de-extinction. Biology & Philosophy 2018; 33: 1-21.

Smith LC, Suzuki Jr J, Goff AK, Filion F, Therrien J, Murphy BD, Kohan-Ghadr HR, Lefebvre R, Brisville AC, Buczinski S, Perecin F, Meirelles FV. Developmental and epigenetic anomalies in cloned cattle. Reproduction in Domestic Animals 2012; 47: 107-114.

Steeves TE, Johnson JA, Hale ML. Maximising evolutionary potential in functio-nal proxies for extinct species: a conservation genetic perspective on de‐extinction. Functional Ecology 2017; 31(5): 1032-1040.

Thiele LP. Nature 4.0: assisted evolution, de-extinction, and ecological restoration technologies. Global Environmental Politics 2020; 20(3): 9-27.

Todesco M, Pascual MA, Owens GL, Ostevik KL, Moyers BT, Hübner S, Heredia SM, Hahn MA, Caseys C, Bock DG, Rieseberg LH. Hybridization and extinction. Evo-lutionary Applications 2016; 9(7): 892-908.

Trecelin AS, Zappa V. Clonagem animal: revisão de literatura. Revista Científica Eletrônica de Medicina Veterinária Garça 2013; (20).

Tumennasan K, Tuya T, Hotta Y, Takase H, Speed RM, Chandley AC. Fertility investigations in the F1 hybrid and backcross progeny of cattle (Bos taurus) and yak (B. grunniens) in Mongolia. Cytogenetic and Genome Research 1997; 78(1): 69-73.

Turvey ST, Crees JJ. Extinction in the Anthropocene. Current Biology 2019; 29(19): R982-R986.

Upadhyay MR, Chen W, Lenstra JA, Goderie CRJ, MacHugh DE, Park SDE, Ma-gee DA, Matassino D, Ciani F, Megens HJ, Arendonk JAM, Groenen MAM. Genetic origin, admixture and population history of aurochs (Bos primigenius) and primitive Eu-ropean cattle. Heredity 2017; 118(2): 169-176.

Valdez RX, Kuzma J, Cummings CL, Peterson MN. Anticipating risks, governance needs, and public perceptions of de-extinction. Journal of Responsible Innovation 2019; 6(2): 211-231.

Whittle PM, Stewart EJ, Fisher D. Re-creation tourism: de-extinction and its implica-tions for nature-based recreation. Current Issues in Tourism 2015; 18(10): 908-912.

Wood JR, Perry GL, Wilmshurst JM. Using palaeoecology to determine baseline ecological requirements and interaction networks for de‐extinction candidate species. Functional Ecology 2017; 31(5): 1012-1020.

Wrigley CA. Ice and Ivory: the cryopolitics of mammoth de-extinction. Journal of Political Ecology 2021; 28(1): 782-803.

Yadav AD, Sahu JD, Dubey AD, Gadpayle RD, Barwa DK, Kashyap K, Jain A, Verma U. An overview on species hybridization in animals. Int. J. Fauna Biol. Stud 2019; 6: 36-42.

Zong E, Fan G. The variety of sterility and gradual progression to fertility in hy-brids of the horse and donkey. Heredity 1989; 62(3): 393-406.

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2023-12-06

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Gomes, W. A., Dutra, D., Sautter, K. D., & Gavinho, B. (2023). Reflexões bioéticas sobre a “desextinção” de espécies. Revista Brasileira De Bioética, 16, 1–28. https://doi.org/10.26512/rbb.v16.2020.34453

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